Publications

2026

169. O’Malley A., Khatri K., Wright E.M., Pittsley R.A., Kowal K., Chruszcz M. (2026) “Calcium-binding proteins as allergens.” Frontiers in Allergy 7, 1759312. DOI: 10.3389/falgy.2026.1759312

Carp parvalbumin (left) and crab sarcoplasmic calcium binding protein (right) are examples of allergens that bind Ca2+ cations. Calcium ions are represented by green spheres.

2025

168. O’Malley A., Offermann L.R., Khatri K., Linn C., Pote S., McBride J.K., Perdue M.L., Hurlburt B.K., Maleki S.J., Mias G.I., Chruszcz M. (2025) “Structural analysis of 8-anilino-1-naphthalene sulfonate (ANS) binding to the PR-10 allergen Ara h 8.” Biochemical and Biophysical Research Communications 793, 153013. DOI: 10.1016/j.bbrc.2025.153013

ANS binding to Ara h 8.0101 (PDB code: 6AWR) and Ara h 8.0201 (PDB code: 6V8M)

167. Khatri K., Ball A., Glesner J., Linn C., Vailes L.D., Wünschmann S., Gabel S.A., Zhang J., Peebles R.S., Borowski T., Mueller G.A., Chapman M.D., Smith S.A., Pomés A., Chruszcz M. (2025) “Human IgE monoclonal antibodies define two unusual epitopes trapping dog allergen Can f 1 in different conformations.” Protein Science 34, e70269. DOI: 10.1002/pro.70269

Can f 1 complexed with two hIgE mAb 1J11 (PDB code: 9NPH) and 12F3 (PDB code: 9NPI) Fabs. The two antibodies bind to two partially overlapping epitopes and recognized two different Can f 1 conformations.

166. Pena-Amelunxen G., Asghari M., Khatri K., Glesner J., Versteeg S.A., van Ree R., Chapman M.D., Smith S.A., Chruszcz M., Pomés A., Aglas L. (2005) “Pre-clinical allergenicity assessment of IgE epitope-targeted Der p 2 mutants demonstrate potential as hypoallergenic AIT candidates.” Frontiers in Immunology 16, 1623920. DOI: 10.3389/fimmu.2025.1623920

Two identified IgE epitopes mapped on surface of Der p 2

165. Wright E.M, O’Malley A., Khatri K., Pittsley R., Offermann L.R., Covert E., Ruan T.F.Y., Ciardiello M.A., Kowal K., Chruszcz M. (2025) “Kiwifruit Allergy – Molecular Basis, Diagnostics and Treatment.” Applied Sciences 15, 7182. DOI: 10.3390/app15137182

Green kiwifruit (Actinidia deliciosa)