Publications

2024

164. O’Malley A., Ray J.M., Kitlas P., Ruethers T., Kapingidza A.B., Cierpicki T., Lopata A., Kowal K., Chruszcz M. (2024) “Comparative studies of seafood and reptile α- and β-parvalbumins.” Protein Science 33, e5226. DOI: 10.1002/pro.5226

Crystal structure of Cro p 1.0101-GFP construct (PDB code: 9BCF). The chimeric construct was design to facilate crystallization of the allergen. Cro p 1.0101 is shown in grey, GFP in green, and linker in teal. Calcium cations are represented by red spheres.

163. Ball A., Khatri K., Glesner J. Vailes L.D., Wünschmann S., Gabel S.A., Mueller G.A., Zhang J., Peebles R.S., Chapman, M.D., Smith S.A., Chruszcz M., Pomés A. (2024) “Structural analysis of human IgE monoclonal antibody epitopes on dust mite allergen Der p 2.” Journal of Allergy and Clinical Immunology 154, 447-457. DOI: 10.1016/j.jaci.2024.04.017

The superimposition of structures of Der p 2 (magenta) in complex with 4C8 (blue; PDB code: 8VK1), 2F10 (gray; PDB code: 7MLH), and 7A1 (green; PDB code: 6OY4).

162. Arriaza R.H, Kapingidza A.B., Dolamore C., Khatri K, O’Malley A., Glesner J. Wuenschmann S., Hyduke N.P., Easley W., Chhiv C., Pomés A., Chruszcz M. (2024) “Structural, Biophysical, and Computational Studies of a Murine Light Chain Dimer.” Molecules 29, 2885. DOI: 10.3390/molecules29122885

The first murine light chain dimer with structure determined and deposited to the Protein Data Bank (PDB code: 8VY6)

161. O’Malley A., Sankaran S., Carriuolo A., Khatri K., Kowal K., Chruszcz M. (2024) “Structural homology of mite profilins to plant profilins is not indicative of allergic cross-reactivity.” Biological Chemistry 405, 367-381. DOI: 10.1515/hsz-2023-0366

Electron density in the area of intact Tyr p 36 Cys12-Cys17 disulfide bridge (PDB code: 8TI6). There are five Cys residues in Tyr p 36, but only two of them form internal disulfide bridge.

160. Linn C., O’Malley A., Khatri K., Wright E.M., Sebagh D., Grbić M., Kowal K., Chruszcz M. (2024) “Microscopic Menaces: The Impact of Mites on Human Health.” International Journal of Molecular Sciences 25, 3675. DOI: 10.3390/ijms25073675

159. Pomés A., Smith S.A., Chruszcz M., Mueller G.A., Brackett N.F., Chapman M.D. (2024) “Precision engineering for localization, validation, and modification of allergenic epitopes.” Journal of Allergy and Clinical Immunology 153, 560-571. DOI: 10.1016/j.jaci.2023.12.017

Cryo-EM structure of Bet v 1 in complex with 3 different Fab fragments of antibodies REGN5713, REGN5714, and REGN5715 (PDB code: 7MXL)

158. Ruffatto K., da Silva C.R., Berté, A.L.W., Grabin S., de Souza E.V., Arriaza R.H., Chruszcz M., Johann L., Sperotto R.A., Timmers L.F.S.M. (2024) “Workflow of structural genomics and bioinformatic approaches to identify natural compounds able to inhibit species-specific proteins in Tetranychus urticae.” Journal of Pest Science 97, 667-683. DOI: 10.1007/s10340-023-01669-7

Sructure of T. urticae dioxygenase that is a potential target for development of acaricides

157. Carey S.M., Kearns S.P., Millington M.E., Buechner G.S., Alvarez B.E. Jr., Daneshian L., Abiskaroon B., Chruszcz M., D’Antonio E.L. (2024) “At the outer part of the active site in Trypanosoma cruzi glucokinase: The role of phenylalanine 337.” Biochimie 218, 8-19. DOI: 10.1016/j.biochi.2023.09.014

Crystal structure of Trypanosoma cruzi glucokinase (F337A mutant) in open conformation. Mutated residues are marked in yellow and shown in sphere representation.